Studies on Chemotherapeutics. XIV

Antifungal chemotherapeutics.

This review addresses trends in outcome and risk factors for invasive fungal infections, current antifungal agents and new therapeutic strategies. Current prospects for new therapies rest upon caspofungin, the first of a new class of antifungal molecules, the echinocandins, and new extended-spectrum azoles, voriconazole, posaconazole and ravuconazole. Approval by the Food and Drug Administratio...

Studies on erythropoiesis. XIV. The relationship of humoral stimulation to iron absorption.

Studies on copper metabolism. XIV. Radioactive copper studies in normal subjects and in patients with hepatolenticular degeneration.

X-ray studies on phospholipid bilayers. XIV. Interactions with the antiarrhythmic asocainol.

Asocainol (ASOC) belongs to class I of the antiarrhythmic drugs, i.e., those that exert their action at the level of the sodium channels of the myocardial cell membrane. It has been suggested that their molecular mechanism of action might be through nonspecific interactions with phospholipids that surround the channel proteins. In order to test this hypothesis, ASOC was made to interact with tw...

XIV International Congress on Mathematical Physics